2022 - present

* Denotes equal contribution. # Denotes co-corresponding authors.


Tran NL*, Jiang J*, Ma M, Gadbois GE, Gulay KCM, Verano AL, Zhou H, Huang CT, Scott DA, Bang AG, Tiriac H, Lowy AM, Wang ES#, Ferguson FM#. ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC. bioRxiv, 2024, DOI: 10.1101/2024.05.19.594824. 


Hope JL, Otero DC, Bae EA, Stairiker CJ, Palete AB, Faso HA, Lin M, Henriquez ML, Roy S, Seo H, Lei X, Wang ES, Chow S, Tinoco R, Daniels GA, Yip K, Rosa Campos A, Yin J, Adams PD, Rao A, Bradley LM. PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion. Cell Rep. 2023 May 30;42(5):112436.

 

Teng M, Jiang J, Wang ES, Geng Q, Toenjes ST, Donovan KA, Mageed N, Yue H, Nowak RP, Wang J, Manz TD, Fischer ES, Cantley LC, Gray NS. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62(18):e202302364.

 

Wang ES, Gray NS. Shining light on reprogramming Tregs for cancer therapy. Cell Chem Biol. 2023 Mar 16;30(3):231-233.

 

Ji W*, Wang ES*, Manz TD*, Jian J*, Donovan KA, Abulaiti X, Fischer ES, Cantley LC, Zhang T, Gray NS. Development of potent and selective degraders of PI5P4Kg. Eur J Med Chem. 2023 Feb 5; 247:115027.

You I, Donovan KA, Krupnick NM, Boghossian AS, Rees MG, Ronan MM, Roth JA, Fischer ES, Wang ES#, Gray NS#. Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation. Cell Chem Biol. 2022 Oct 6.

Verano AL*, You I*, Donovan KA, Mageed N, Yue H, Nowak RP, Fischer ES, Wang ES#, Gray NS#. Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios. ACS Chem Biol. 2022 Sep 16;17(9):2404-2410.



2006 - 2021

*denotes equal contribution

Wang ES*, Verano AL*, Nowak RP*, Yuan JC*, Donovan KA, Eleuteri NA, Ngo KH, Gokhale PC, Gray NS, Fischer EF. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun; 17(6):711-717.

Powell CE, Du G, Che J, He Z, Donovan KA, Yue H, Wang ES, Nowak RP, Zhang T, Fischer ES, Gray NS. Selective degradation of GSPT1 by Cereblon modulators identified via a focused combinatorial library. ACS Chem Biol. 2020 Oct 16; 15(10):2722-2730.

Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG Jr, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2020 Jan 13;37(1):37-54.e9.

Jiang B*, Wang ES*, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS. Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6. Agnew Chem Int Ed Engl. 58(19):6321-6326, 2019.

Dobrovolsky D*, Wang ES*, Morrow S*, Leahy C, Faust T, Nowak RP, Donovan KA, Yang G, Li Z, Fischer ES, Treon SP, Weinstock DM, Gray NS. Bruton’s Tyrosine Kinase Degradation as a Therapeutic Strategy for Cancer. Blood. 133(9):952-961, 2019.

Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 26(2):300-306, 2019.

Deng J*, Wang ES*, Jenkins RW*, et al. CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T- cell Activation. Cancer Discov. 8(2):216-233, 2018.

Jenkins RW, Aref AR, Lizotte PH, Ivanova E, Stinson S, Zhou CW, Bowden M, Deng J, Liu H, Miao D, He MX, Walker W, Zhang G, Tian T, Cheng C, Wei Z, Palaurthi S, Bittinger M, Vitzthum H, Kim JW, Merlino A, Quinn M, Venkataramani C, Kaplan JA, Portell A, Gokhale PC, Phillips B, Smart A, Rotem A, Jones RE, Keogh L, Anguiano M, Stapleton L, Jia Z, Rokni MB, Cañadas I, Thai TC, Hammond MR, Vlahos R, Wang ES, Zhang H, Li S, Hanna GJ, Huang W, Hoang MP, Piris A, Eliane JP, Stemmer-Rachamimov AO, Cameron L, Su MJ, Shah P, IZar B, Thakuria M, LeBoeuf NR, Rabinowitz G, Gunda V, Parangi S, Cleary JM, Miller BC, Kitajima S, Thummalapalli R, Miao B, Barbie TU, Sivathanu V, Wong J, Richards WG, Bueno R, Yoon CH, Miret J, Herlyn M, Garraway LA, Van Allen EM, Freeman GJ, Kirschmeier PT, Lorch JH, Ott PA, Hodi FS, Flaherty KT, Kamm RD, Boland GM, Wong KK, Dornan D, Paweletz CP, Barbie DA. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 8(2):196-215, 2018.

Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Letters. 9(6):540-545, 2018.

Wang ES*, Reyes NA*, Melton C*, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA. Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation. Curr Biol. 25(23):3110-8, 2015.  

Ghosh R*, Wang L*, Wang ES*, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress. Cell. 158(3):534–548, 2014.

Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.  IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 338(6108):818-22, 2012.

Wang ES, Dobrikova E, Goetz C, Dufresne AT, Gromeier M. Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract. J Virol. 85(11):5606-17, 2011.

Moharram R, Maynard D, Wang ES, Makusky A, Murray GJ, Martin BM.  Reexamination of the cysteine residues in glucocerebrosidase. FEBS Lett. 580(14):3391-4, 2006.